http://www.eurosciconpodcasts.com Narrated meeting reports from selected Life Science meetings en-PI http://creativecommons.org/licenses/by/2.0/ JellyCast http://www.jellycast.com sharacohen@euroscicon.com (euroscicon) Science Tue, 11 Jul 2006 10:16:27 +0100 Fri, 11 Aug 2006 22:03:53 +0100 https://euroscicon.jellycast.com/files/smallellycastlogo.png http://www.eurosciconpodcasts.com 144 144 Narrated meeting reports from selected Life Science meetings Euroscicon euroscicon sharacohen@euroscicon.com podcast No No Narrated meeting reports from selected Life Science meetings The audio files on this web site are the abbreviated meeting reports from selected Euroscicon Life Science meetings. Euroscicon host unbiased events where scientists from many fields can participate and offer their own experiences of technology that can help improve the experiments of others. Each event is an opportunity for industry and academia to share discussion, new bonds and new ideas for the future. "Specialising in communicating cutting edge technology & methodology in the Life Sciences" https://euroscicon.jellycast.com/node/26 While in the last few years genomic and proteomic projects advanced uninterruptedly, understanding glycans still prsents several difficulties: they have a non-template driven biosynthesis, there is no system for the amplification of carbohydrates, and their characterization is still complicated. Moreover, the glycosylation patterns are complex and carbohydrate homeostasis requires considerable cellular control. Fortunately, Glycomics is advancing: the new technologies developed, the optimized experimental strategies and the Bioinformatics tools are making their move. On November 28, 2006 Euroscicon Conference “Glycomics: Challenges and Technologies” was held in London, and depicted an optimistic view of the advances in the area. This conference covered some of the new technologies that makes Glycomics move forward: Mass spectrometry, glycan microarrays, carbohydrate chemistry. Bioinformatics approaches advances in development of tools for data handling were also described. The concept that functional glycomics (large-scale analysis of the biological functions of the glycome) requires an integrated system approach to the structure-function relationships was remarked by several scientists during the day. The conclusions after the meeting were concise: powerful new technologies are coming into play. Predictions from genomics or transcriptomics data concerning the biosynthesis of the glycome, and glycan binding protein receptors are difficult, but the array of technologies and approaches that are now forming the glycomics field (including arrays, MS, chemical libraries, natural saccharide libraries, bioinformatics, genomic/transcriptomic data, bioassays and in vivo systems and disease processes) could be expected to provide new insights in the function of the glycome, and lead to new and exciting applications, including diagnostics and new routes to therapeutics. Thu, 11 Jan 2007 11:45:15 +0000 Content https://euroscicon.jellycast.com/node/26 euroscicon https://euroscicon.jellycast.com/node/26 No glycomics 00:02:45 https://euroscicon.jellycast.com/node/25 On October 6th, 2006 a group of experts on fish disease, diagnosis and treatment assembled in London to share recent advances in the field. Fish disease significantly impacts environmental balance and commercial productivity on a global basis. Losses have high economic consequences, especially in areas where fishing or aquatic farming and culture are important community-supporting industries. Thu, 11 Jan 2007 11:48:56 +0000 On October 6th, 2006 a group of experts on fish disease, diagnosis and treatment assembled in London to share recent advances in the field. Fish disease significantly impacts environmental balance and commercial productivity on a global basis. Losses have high economic consequences, especially in areas where fishing or aquatic farming and culture are important community-supporting industries. https://euroscicon.jellycast.com/node/25 euroscicon https://euroscicon.jellycast.com/node/25 Fish disease, diagnosis and treatment On October 6th, 2006 a group of experts on fish disease, diagnosis and treatment assembled in London to share recent advances in the field. Fish disease significantly impacts environmental balance and commercial productivity on a global basis. Losses have high economic consequences, especially in areas where fishing or aquatic farming and culture are important community-supporting industries. No fish,disease 00:01:33 https://euroscicon.jellycast.com/node/24 On the 17th of November 2006 Euroscicon hosted a conference entitled ‘Tissue Engineering Today, Not Tomorrow’ at the MI Centre in London. The conference covered some of the key issues in tissue engineering including the use of embryonic and mesenchymal stem cells, the development of new generations of biomaterials and scaffolds, and the use of methods which will allow the implantation of tissue engineered constructs without evoking an immune response. The conference was chaired by Professor Anne Dickinson from the University of Newcastle and was opened by Dame Julia Polak from Imperial College, London. Dame Polak presented an overview of the major issues in regenerative medicine, from the choice of cells and scaffolds through to methods of scale-up, the choices for cell delivery and the requirements of pre-clinical and clinical phase applications. Alongside the choice of cells, the correct scaffold is a key determinant in a successful tissue engineering system and the recent developments mean that new generations of multifunctional biomaterials are now available. Several talks throughout the day covered this theme, with Professor Nureddin Ashammakhi from Keele University giving an overview of the various generations of scaffolds, from the first bioinert, biodegradable scaffolds to more recent third generation biomaterials, which are tailor-made and incorporate bioactive molecules which can aid cell division, differentiation or matrix synthesis and can also help prevent infection at the implant site. Talks were also given by Mrs T Morton (Ludwig Boltzman Institute for Experimental and Clinical Traumology, Vienna, Austria), Dr Hossein Hosseinkhani (National Institute for Materials Sciences, Japan), Professor Kevin Shakesheff’s (University of Nottingham) and Professor Julian Chaudhuri (University of Bath) on application specific scaffolds and hydrogels. A number of presentations throughout the day also covered the issue of immune rejection of transplanted cells and tissues. The first was by Dr Paul Fairchild (University of Oxford), who talked about embryonic stem cells, while later talks by Dr S Wolbank (Red Cross Transfusion Centre for Upper Austria, Austria), Dr Xiao Nong-Wang (University of Newcastle) and Dr Marta Calatayud (Vall d’Hebron Hospital, Barcelona, Spain) concentrated on adult stem cells. The methods of modulating the immunogenicity of both cell types was discussed and clinical trial evidence was given for the efficacy of these methods. Final, a range of analytical methods to study cells and tissues was covered. Novel methods for isolating stem cells was discussed by Mrs Susan Donath of Miltenyi Biotec, Germany; Professor Farzin Farzaneh from Kings College, London discussed functional gene analysis to identify stem cell regulatory factors; Dr Catherine Sarraf from Westminster University discussed analysis of the effects of load on cells; and Dr Andre Neves from the University of Cambridge described MRI-based methods of analysing engineered tissues. This excellent conference revealed that the fields of stem cells, tissue engineering, gene therapy, nanotechnology and regenerative medicine are all converging for clinical application and demonstrated that tissue engineering has huge potential for the treatment of countless medical conditions. Sun, 10 Dec 2006 22:43:06 +0000 Content https://euroscicon.jellycast.com/node/24 jellycast https://euroscicon.jellycast.com/node/24 No Podcast 00:04:14 https://euroscicon.jellycast.com/node/18 A one day Euroscicon event This ABBERVIATED meeting report was written by Laura Smith of the Cancer Biology Proteomics Group in the Postgraduate Medical Institute In AT Hull York Medical School And narrated by DR Shara Cohen, managing director of euroscicon A full version of this report can be found at www.eurosciconpodcasts.com and a more formal meeting report can be found in the December 2006 issue of Expert Reviews in Proteomics Dr Robin Wait (from the Kennedy Institute of Rheumatology in London) chaired this highly informative Euroscicon event which was held on Sept 29th 2006. To summaries the meeting • Professor David O’Connor (Centre for Proteomic Research, Southampton) described some new methods that are being developed to capture more of the proteome • Dr Paru Oatey (Syngene, UK) described advances in the capture and analysis of 2D gel images from both fluorescent and visible stained gels by introducing the Dyversity imaging system and the Dymension software package. • Dr Dan Gare (LI-COR Biosciences Ltd, UK) continued the theme of imaging by describing the LI-COR Odyssey imaging system for protein quantification and western blotting applications. • Dr Robert Edwards (Experimental Medicine and Toxicology, Imperial College London,) discussed the use of surface-enhanced laser desorption/ ionisation time-of-flight mass spectrometryand fractionation in combination with LC-MS/MS for the analysis of oestrogen-mediated cell biology. • Dr Balwir Matharoo-Ball (Proteomics and Mass Spectrometry, Nottingham Trent University) described the use of a top-down bottom-up approach for the discovery of biomarkers for the diagnosis and prognosis of melanoma. • Dr Christoph Eckerskorn (BD Diagnostics, Germany) introduced the BD Free Flow Electrophoresis (FFE) System and discussed some recent applications including subcellular fractionation of complex proteomes. • Mr Jim Thorn (Beckman, UK) introduced the ProteomeLab PF2D system and presented data demonstrating the utility of this system for biomarker discovery. • The talk by Mr Kevin Jones (GenoLogics, UK) discussed the advantages of using the ProteusLimsTM comprehensive laboratory instrument and data management system for proteomics research. • Dr Maria Krestyaninova (European Bioinformatic Institute, Cambridge, UK) continued the theme of bioinformatics and data handling by describing data management in the Molecular Phenotyping to Accelerate Genomic Epidemiology programme. • Dr Laurence Lamarcq (Clontech-TakaraBioEurope, France) focussed on the use of novel antibody microarray technology and introduced the ClontechTM Antibody (Ab) Microarray 500 for the analysis of over 500 proteins in a single experiment. • Professor Tony Cass (Institute of Biomedical Engineering, Imperial College London, UK) discussed the role of nanotechnology in proteomics focussing on the use of nano-particles as labels. In particular, the use of precious metal nano-particles was described, an example of which includes aptamer-conjugated gold metallic nano-particles. Dr Andy Pitt (University of Glasgow, UK) focussed on the rapid progress being made in proteomics technology and described recent advances in separation methods (e.g. capillary electrophoresis coupled with mass spectrometry), imaging (e.g. MALDI-TOF MS imaging), microarrays (e.g. protein-interaction and aptamer microarrays) and bioMEMS systems. • The final talk of the day was given by Dr Lamarcq (Clontech-TakaraBioEurope, France), which described the seamless In-FusionTM PCR cloning system for optimised protein expression for high throughput applications. • In conclusion, this interesting meeting highlighted some of the latest technological advances enabling a larger portion of the expressed proteome to be captured • Please go to www.eurosciconpodcasts.com for a full version of th e report Sun, 10 Dec 2006 22:42:47 +0000 Content https://euroscicon.jellycast.com/node/18 euroscicon https://euroscicon.jellycast.com/node/18 A one day Euroscicon event No put some keywords here 00:04:32 https://euroscicon.jellycast.com/node/17 EuroSciCon's focus on novel methods and their applications was at the fore in this informative London meeting, held on the 4th April 2006, covering some of the latest findings on regulatory T cells. The popularity of this field was reflected by the number of delegates with a lively audience of 150 research scientists filling the Birkbeck lecture theatre. Talks covered the methodology of regulatory T cell isolation, quantification and expansion and data were presented from the fields of reproductive immunology, autoimmunity, inflammation (collitis) and transplantation Fri, 11 Aug 2006 22:08:04 +0100 Content https://euroscicon.jellycast.com/node/17 jellycast https://euroscicon.jellycast.com/node/17 No Podcast 00:04:07